中文摘要：

探究脑卒中后抑郁症（PSD）患者脑网络异常。采集PSD患者及其对照组（卒中后无抑郁症（PSND）患者及健康人（CONT））各10例16导联静息态脑电信号进行偏定向相干性（PDC）分析,利用单尾单样本t检验构建这3类人群的平均脑网络图,并对所得脑网络进行基于图论的拓扑参数比较分析。结果表明,经统计学检验（P〈0.05）,当PDC阈值取0.2时,三类人群平均脑网络节点度、平均集群系数及中介中心度参数差异最明显。具体表现为脑卒中患者相对健康人出现了优势半球（左半球）信息流入的减弱,PSD患者相对PSND患者在与＂情绪＂相关的左额叶及左颞叶信息流出减弱。PSD患者相对CONT及PSND人群平均集群系数分别下降2.4%及1.8%,脑网络集团化程度减弱;网络核心节点个数分别增大2.2倍及1.6倍,且核心节点有所转移,枢纽节点核心地位下降。受脑卒中和抑郁情绪的影响,PSD患者的脑网络发生了异常改变。

英文摘要：

The aim of our study is to investigate the abnormal brain network of poststroke depression（ PSD）patients. Sixteen channels of resting state EEG of respectively 10 cases of PSD patients and control groups（ poststroke non-depression（ PSND） and healthy controls（ CONT）） were collected for partial directed coherence（ PDC） analysis. The average brain network diagrams for the three populations were built according to the one-tailed single sample t test. Some parameters based on topology graph theory were compared among the three populations. According to the statistical test（ P〈0. 05）,apparent difference was performed among the three groups in the brain network parameters of degree,average cluster coefficient and betweenness centrality when PDC = 0. 2. Compared with healthy subjects,stroke patients showed decreased information inflow to the dominant hemisphere（ left）. PSD patients performed weaker outflow information than PSND subjects in＂emotional＂related regions such as left frontal lobe and left temporal lobe. Comparatively to CONT and PSND populations,the cluster coefficient of PSD patients decreased by 2. 4% and 1. 8% respectively,indicatingdeclined collectivization degree of brain network. The number of ＂core nodes＂in PSD patients increased 2. 2times and 1. 6 times respectively,showing transferred core nodes and lower core status. Affected by stroke and depressed mood,PSD patients performed abnormal brain networks.