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1970～2004年全球肠道病毒71型分离株的分子流行病学分析
  • ISSN号：0023-074X
  • 期刊名称：《科学通报》
  • 时间：0
  • 分类：S852.659.5[农业科学—基础兽医学;农业科学—兽医学;农业科学—畜牧兽医]
  • 作者机构：[1]清华大学生物科学与技术系分子免疫学实验室,蛋白质科学教育部重点实验室,北京100084
  • 相关基金：国家自然科学基金（批准号：30221003）资助项目
作者： 董晓楠[1], 应剑[1], 陈应华[1]
关键词： 肠道病毒71型(EV71), VP1, 流行病学, 共变异
中文摘要：

人类肠道病毒71型（EV71）是引起手足口病的主要病原体,常导致严重的神经系统综合征.近年来病毒多爆发于亚太地区的热带区域.为研究人类肠道病毒的进化历程以及遗传变异性,搜集了全球在1970～2004年间分离的532株病毒的序列信息,这些信息包含了完整或接近完整的VP1区核苷酸序列（891bp）.经过系统发生学分析以及遗传距离的比较,发现绝大多数病毒株属于基因型B或C.同时也观察到一种特殊的不属于任何现有分型的毒株R13223-IND-01,可能代表了一种新的基因型.在B型和C型病毒中,存在着一些区别于同型其他亚型毒株的“孤儿株”,它们的出现在病毒进化分析中有重要的意义.此外,VP1片段上有6个散在位点的氨基酸存在共变异的现象,分析发现这种高比例的共变异与病毒亚型有着紧密的联系.

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期刊信息
  • 《科学通报》
  • 北大核心期刊（2011版）
  • 主管单位:中国科学院
  • 主办单位:中国科学院
  • 主编：周光召
  • 地址：北京东黄城根北街16号
  • 邮编：100717
  • 邮箱：csb@scichina.org
  • 电话：010-64036120 64012686
  • 国际标准刊号：ISSN：0023-074X
  • 国内统一刊号：ISSN：11-1784/N
  • 邮发代号:80-213
  • 获奖情况:
  • 首届国家期刊奖,中国期刊方阵“双高”期刊,第三届中国出版政府奖
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  • 被引量:81792