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Molecular epidemiology and evolution of worldwide enterovirus 71 strains isolated from 1970 to 2004
  • ISSN号：1000-3282
  • 期刊名称：《生物化学与生物物理进展》
  • 时间：0
  • 分类：R3[医药卫生—基础医学]
  • 作者机构：[1]Protein Science Laboratory of Ministry of Education/Laboratory of Immunology, Department of Biology, Tsinghua University, Beijing100084, China
  • 相关基金：Supported by the National Natural Science Foundation of China （Grant No. 30221003）
作者： DONG XiaoNan YING Jian CHEN YingHua[1]
关键词： 肠道病毒71, 流行病学, 可变性, 钴, enterovirus 71 （EV71）, VP1, epidemiology, co-variability
中文摘要：

人的 enterovirus (EV71 ) 71 是经常引起严重神经病学的复杂并发症的 thehand-foot-and-mouth 疾病(HFMD ) 的主要 etiological 代理人之一。最近，它的爆发主要发生在亚太区域的炽热的地区。学习进化和基因可变性，我们与从 1970 ～ 2004 全球孤立的几乎完全或完全的 VP1sequences (891 nt ) 收集了 532 EV71 紧张。对明智的相同和基因距离被分析。大多数紧张属于以前识别的遗传型 B 和 C。然而，唯一的种类 R13223-IND-01 看起来不掉进电流三遗传型(A， B 和 C ) ，并且可能代表新遗传型 D。一些孤儿种类在遗传型 B 和 C 被观察，并且他们在 EV71 进化的意义被讨论。而且，有 VP1 (氨基酸 43， 58,164,184， 240 和 249 ) 上的 6 个分离位置的一个 significantco 变化。这 highco 可变性紧与潜水艇遗传型被联系。

英文摘要：

Human enterovirus 71 （EV71） is one of the major etiological agents of the hand-foot-and-mouth disease （HFMD） that often causes severe neurological complications. Recently, its outbreaks mainly take place in the torrid zone of the Asia-Pacific region. To study the evolution and genetic variability, we collected 532 EV71 strains with almost complete or complete VP1 sequences （891 nt） isolated worldwide from 1970 to 2004. The pairwise homologies and genetic distances were analyzed. Most strains belong to previously identified genotype B and C. However, a unique strain R13223-1ND-01 appears not to fall into current three genotypes （A, B and C）, and probably represents a new genotype D. Some orphan strains were observed in the genotypes B and C, and their significance in the EV71 evolution was discussed. Moreover, there is a significant co-variance of 6 discrete positions on VP1 （amino acid 43, 58, 164, 184, 240 and 249）. This high co-variability is tightly related with the subgenotypes.

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期刊信息
  • 《生物化学与生物物理进展》
  • 中国科技核心期刊
  • 主管单位:中国科学院
  • 主办单位:中国科学院生物物理研究所 中国生物物理学会
  • 主编：王大成
  • 地址：北京市朝阳区大屯路15号
  • 邮编：100101
  • 邮箱：prog@sun5.ibp.ac.cn
  • 电话：010-64888459
  • 国际标准刊号：ISSN：1000-3282
  • 国内统一刊号：ISSN：11-2161/Q
  • 邮发代号:2-816
  • 获奖情况:
  • 1999年中国期刊奖提名奖,2000年中国科学院优秀期刊特别奖
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,荷兰文摘与引文数据库,美国剑桥科学文摘,美国科学引文索引（扩展库）,美国生物科学数据库,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,中国北大核心期刊（2000版）
  • 被引量:18821