中文摘要：

目的制备宝藿苷Ⅰ磷脂复合物,并考察其体外抗肿瘤活性。方法采用溶剂法制备宝藿苷Ⅰ磷脂复合物,应用差示扫描量热法（DSC）和X-射线粉末衍射法（XRD）对所制得的磷脂复合物进行表征,通过细胞毒性和细胞摄取实验考察其体外抗肿瘤活性。结果差示扫描量热法和X-射线粉末衍射法图谱结果显示成功制备宝藿苷Ⅰ磷脂复合物,MTT实验表明,将宝藿苷Ⅰ制备成磷脂复合物后,其对乳腺癌细胞MCF-7增殖的抑制作用增强,细胞对药物的摄取率也有一定的提高。结论与宝藿苷Ⅰ相比,宝藿苷Ⅰ磷脂复合物的抗肿瘤活性有所增强。

英文摘要：

OBJECTIVE To prepare baohuoside Ⅰ phytosomes and study its anti-tumor activities in vitro. METHODS The bao- huoside Ⅰ phytosomes was prepared using solvent evaporation method. The phytosomes was analyzed using differential scanning calorim- etry （DSC） and X-ray powder diffraction （XRD）. Cell toxicity and uptake assays were employed to evaluate the anti-tumor activities of the phytosomes in vitro. RESULTS DSC and XRD analysis suggested that the baohuoside Ⅰ phytosomes was successfully prepared. MTT assay showed that the inhibition on breast cancer MCF-7 ceils by baohuoside Ⅰ phytosomes increased while the uptake rate was improved. CONCLUSION The baohuoside Ⅰ phytosomes has a more effective anti-tumor activity than baohuoside Ⅰ.