中文摘要：

Y盒结合蛋白1（YB-1）是一类包含冷休克结构域的蛋白家族成员,YB-1从结构上分为三部分：N端的单链DNA结构域、冷休克结构域和C端结构域.它与DNA及RNA的相互作用、转录调节、翻译调控等有关.YB-1参与肿瘤细胞的转化、多重耐药及转移.YB-1对肿瘤具有促进和抑制作用,可作为诊断肿瘤的重要指标,是治疗肿瘤的重要的分子靶点.总之,YB-1不仅在肿瘤细胞的生长中起重要作用,而且在肿瘤相关的血管内皮细胞生长中也扮演着重要的角色.该文就YB-1的功能及其对肿瘤发生的促进及抑制等方面进行概述.

英文摘要：

Y-box binding protein-1 （ YB-1 ） is a member of the cold shock protein family. YB-1 contains three structure domains, namely the N-terminal domain, the hydrophilic C-terminal domain and the conserved cold shock domain（CSD） ,which is involved in the interaction of YB-1 with DNA and RNA,transcriptiorial and translational regulation of various genes. YB-1 is involved in oncogenic cell transformation, multiple drug resistance, and dissemination of tumor. YB-1 has both the oncogenic and antioncogenic function, and can be used as an important indicator for tumor diagnosis and a molecular target for tumor treatment. In short,YB-1 plays an important role in the growth of not only tumor ceils but also tumor-associated vascular endothelial cells. Here is to make a review of the function of YB-1 and its oncogenic and antioncogenic roles in the tumorigenesis.