中文摘要：

目的：探讨围术期哮喘患者气道管理中应用氢化可的松琥珀酸钠的效果。方法选择林州市人民医院围术期中建立人工气道的哮喘患者47例，按随机数字表法分为对照组（24例）和治疗组（23例）。对照组围术期静脉滴注（静滴）多索茶碱300 mg；治疗组在静滴多索茶碱300 mg的同时加氢化可的松琥珀酸钠500 mg静脉注射（静注）。观察两组患者的哮喘缓解情况及生命体征、动脉血气及呼吸功能的变化。结果治疗组和对照组30 min哮喘缓解率和无效例数比较差异无统计学意义（均P＞0.05）；治疗组治疗后1 h哮喘缓解率明显高于对照组（95.7%比66.7%，P＝0.023），平均缓解时间短于对照组（min：38.09＆#177;15.93比45.83＆#177;18.75，P＝0.012），且呼吸频率（RR）降低（次/min：20.8＆#177;2.3比22.3＆#177;3.3，P＝0.042），动脉血氧分压〔PaO2（mmHg，1 mmHg＝0.133 kPa）：83.5＆#177;8.9比77.9＆#177;7.4，P＝0.028〕、乳酸〔Lac（mmol/L）：1.87＆#177;0.29比2.09＆#177;0.33，P＝0.029〕、用力肺活量〔FVC（L）：3.84＆#177;0.23比3.65＆#177;0.31，P＝0.004〕和1秒用力呼气容积〔FEV1（L）：3.34＆#177;0.20比3.16＆#177;0.29，P＝0.003〕均较对照组明显升高，但心率（HR）、动脉血氧饱和度（SaO2）、pH值、动脉血二氧化碳分压（PaCO2）、FEV1/FVC、呼气峰流速（PEF）与对照组比较差异均无统计学意义（均P＞0.05）。结论氢化可的松琥珀酸钠联合多索茶碱可以更快缓解围术期建立人工气道患者的哮喘症状。

英文摘要：

Objective To explore the effect of hydrocortisone sodium succinate on perioperative airway management in bronchial asthma patients. Methods 47 perioperative bronchial asthma patients with artificial airway in Linzhou City People Hospital were enrolled,and they were randomly divided into control group（24 cases） and therapy group（23 cases）. Doxofylline 300 mg intravenous（IV）drip per day was given to the patients in both groups,and in therapy group,additionally hydrocortisone sodium succinate 500 mg IV drip per day was applied. The remission of asthma and changes in vital signs,arterial blood gas and respiratory function were observed in both groups. Results There were no significant differences in remission rate and invalid number at 30 minutes after treatment between therapy group and control group（both P＆gt;0.05）. The remission rate of asthma in therapy group at 1 hour after treatment was significantly higher than that in control group（95.7%vs. 66.7%,P=0.023）,the mean remission time was shorter than that in control group（minutes：38.09＆#177;15.93 vs. 45.83＆#177;18.75,P=0.012）,the respiratory rate was lower（beats/min：20.8＆#177;2.3 vs. 22.3＆#177;3.3,P=0.042）,and arterial partial pressure of oxygen〔PaO2（mmHg,1 mmHg=0.133 kPa）：83.5＆#177;8.9 vs. 77.9＆#177;7.4,P=0.028〕,lactate〔Lac（mmol/L）：1.87＆#177;0.29 vs. 2.09＆#177;0.33,P=0.029〕,forced vital capacity〔FVC（L）：3.84＆#177;0.23 vs. 3.65＆#177;0.31,P=0.004〕and forced expiratory volume in 1 second〔FEV1（L）：3.34＆#177;0.20 vs. 3.16＆#177;0.29,P=0.003〕were significantly increased compared with those in control group. But there were no significant differences in heart rate（HR）,arterial oxygen saturation（SaO2）,pH value,arterial partial pressure of carbon dioxide（PaCO2）,FEV1/FVC,and peak expiratory flow （PEF）between the two groups（all P＆gt;0.05）. Conclusion Hydrocortisone sodium succinate in conjunction with doxofylline can relax the symptom of perioperative bronchia