中文摘要：

甲基化对胚胎发育和机体形成具有重要的调控作用,体细胞核移植胚胎常常表现出异常的DNA甲基化,DNA甲基转移酶抑制剂能抑制细胞的DNA甲基化水平,从而达到提高体细胞核移植效率的作用。作者主要综述了DNA甲基转移酶抑制剂在动物体细胞核移植研究中的应用。

英文摘要：

Methylation plays an important regulatory role in embryo development and organization.Somatic nuclear transfer embryos often show the abnormal mode of DNA methylation,DNA methyltransferase inhibitors can inhibit the levels of DNA methylation,so as to improve the efficiency of SCNT.The application of DNA methyltransferase inhibitors in animal somatic cell nuclear transfer was taken an overview in this paper.