中文摘要：

胚胎干细胞（embryonic stem cells,ES）是从早期囊胚内细胞团分离培养出来的能够不断维持自我更新和具有发育多能性的细胞。Wnt信号通路在维持胚胎干细胞的自我更新方面起着重要作用,糖原合成激酶（glycogen synthase kinase-3,GSK-3）抑制剂可以激活Wnt信号通路,促进胚胎干细胞自我更新和增强细胞间连接。作者就GSK-3抑制剂在胚胎干细胞自我更新、细胞连接方面的作用及其作用机制进行简单综述。

英文摘要：

Embryonic stem（ES）cells are derived from the inner cell mass of early blastocyst, and possess the ability of self-renewal and maintenance pluripotency.Wnt signaling pathway plays important roles in maintaining self-renewal of ES cells.Glycogen synthase kinase-3（GSK-3） inhibitors can active Wnt signaling pathway,then promote the self-renewal and cellto-cell adhesion of ES cells.In this paper,we take a review for the effect and mechanism of GSK-3 inhibitors on maintaining self-renewal and cell-to-cell adhesion of ES cells.