中文摘要：

目的：探讨新疆维、汉人群变应性鼻炎（Allergic rhinitis,AR）患者血清白细胞介素4（Interleukin-4,IL-4）和干扰素γ（Interferon gamma,IFN-γ）水平与鼻粘膜嗜酸性粒细胞（Eosionphils,EOS）浸润的相关性。方法：采用酶联免疫吸附法（Enzyme-linked immunosorbnent assay,ELISA）测定59例维吾尔族AR患者、50例汉族AR患者外周血清IL-4和IFN-γ水平,高倍显微镜下观察病理涂片并计数AR患者鼻粘膜EOS计数。结果：维、汉人群AR患者血清IL-4和IFN-γ水平均无显著差异（t值分别为1.304和1.408,P均〉0.05）;维、汉人群AR患者IL-4水平与鼻粘膜嗜酸性粒细胞计数均呈正相关（r分别为0.828和0.691,P均〈0.01）,IFN-γ水平与鼻粘膜EOS计数均呈负相关（r分别为-0.712和-0.764,P均〈0.01）。结论：维、汉人群AR患者的血清IL-4和IFN-γ水平均无显著差异,AR患者鼻粘膜EOS增多与血清IL-4分泌过多而IFN-γ分泌受抑制有关。

英文摘要：

Objective：To evaluate the correlation of serum IL-4 and IFN-γ level and nasal mucosa eosinophilic in Xinjiang Uygur,Han people allergic rhinitis patients.Methods：Through double-antibody Enzyme-linked Immunosorbent Assay（ELISA） 59 cases Uygur AR patients,50 patients Han＇s AR serum IL-4 and IFN-γ levels were analyzed,pathology smear was observed at high-power microscope and counting AR patients nasal smear eosinophil count.Results：There were not significantly different between Uygur and Han population of patients with allergic rhinitis serum IL-4 and IFN-γ levels（t values were 1.304 and 1.408,P0.05）,Uygur and Han IL-4 levels of AR patients and nasal eosinophil counts were positively correlated（r=0.828 and 0.691,P0.01）,IFN-γ levels and nasal eosinophil count was negatively correlated（r=-0.712 and-0.764,P0.01）.Conclusion：There were not significantly difference between Uygur and Han population of patients with allergic rhinitis serum IL-4 and IFN-γ levels.There were connection with excess secretion of serum IL-4 and inhibition secretion of IFN-γ and Uggur,Han peopeo allergic rhinitis nasal eosinophil counts.