中文摘要：

目的：探讨辛芷鼻敏胶囊对变应性鼻炎（AR）大鼠骨髓及外周血中IL-5和外周血及骨髓中嗜酸性粒细胞（EOS）的影响。方法：用卵清蛋白（OVA）致敏SD大鼠制成模型,分正常对照组、模型组、鼻炎康组、辛芷鼻敏胶囊组,分别ig生理盐水、鼻炎康片（3 g·kg^-1）和辛芷鼻敏胶囊（3.6 g·kg^-1）,连续10 d。采用双抗体夹心酶联免疫吸附技术（ELISA）定量测定骨髓及外周血中白介素-5（IL-5）含量,骨髓和外周血涂片瑞氏染色计数EOS。结果：辛芷鼻敏胶囊组骨髓及外周血中IL-5,EOS比模型组有显著降低（P〈0.05）,且与鼻炎康组比较有统计学意义（P〈0.05）;辛芷鼻敏胶囊组大鼠鼻黏膜EOS计数明显低于模型组和鼻炎康组（P〈0.01,P〈0.05）。结论：辛芷鼻敏胶囊可以减少IL-5水平,减少嗜酸性粒细胞浸润,而起到一定的治疗作用。

英文摘要：

Objective：To investigate effect of Xinzhi Bimin capsule on the model of rats with allergic rhinitis（AR） and the effect on Interleukin-5（IL-5） and eosinophil（EOS）.Method：Fourty rats were randomly divided into control group,sensitized group,the positive control（Beiyankang,3 g·kg^-1） and experimental groups（3.6 g·kg^-1）.The rats were sensitized by ovalbumin.Result：IL-5 content in bone marrow of the experimental group was significantly lower than those of the model group and the positive control group（P 〈 0.05）;IL-5 content of blood serum in the experimental group was significantly lower than those of the model group and the positive control group（P 〈0.05）;the numbers of EOS,compared with the control group and the model group,there were significant difference（P 〈 0.05）.Conclusion：Xinzhi Bimin capsule can reduce IL-5 content of bone marrow and in serum,and relieve EOS infiltration.