中文摘要：

HNK-1聚糖是广泛存在于人类自然杀伤细胞抗原及诸多黏附分子中的一种特殊物质，其参与细胞识别、黏附和迁移等行为，对神经系统生长发育的调节、外周神经系统中运动神经元的再生以及神经细胞突触可塑性的调节均有促进作用。简介HNK-1聚糖的结构和体内分布，着重讨论其在神经系统中的作用及其在疾病诊断和治疗方面的应用前景，为开发与HNK-1聚糖功能类似的神经退变性疾病治疗药物提供参考。

英文摘要：

HNK-1 glycan is a special material, which exists widely in human natural killer cell antigen and a number of adhesion molecules. It may be related with cell recognition, adhesion and migration. Moreover, it could promote several functions such as regulation of the growth and development of the nervous system, motor neurons regeneration of peripheral nervous system, as well as the regulation of neuronal synaptic plasticity. The structure, the tissue distribution and physiological function of HNK-1 glycan, especially its effects on nervous system and the application in medical field were introduced, to provide a reference for the development of the new drugs which have the analogous functions of HNK-1 glycan and can be used to treat degenerative neurological diseases.