中文摘要：

目前我国有1 249多万人感染华支睾吸虫（Clonorchis sinensis），国内胆管癌的发病率亦不断增长。100多年前就有研究者提出华支睾吸虫感染与胆管癌的发生有关，并致力于其发生机制的研究，但其具体机制至今尚未明确，因此，研究两者之间的关系具有重要意义。本文从虫体机械损伤、分泌代谢产物的刺激以及机体免疫反应异常、分子和基因突变等方面对华支睾吸虫感染与胆管癌发生发展关系及其可能机制进行综述。

英文摘要：

Currently， 12.49 million people are infected with Clonorchis sinensis in China. The incidence of bile duct carcinoma increased for recent years. More than a century ago， some scholars have put forward the idea about the relations between C. sinensis infection and cholangiocarcinoma， and committed to research the mechanism. However， the intrinsic mechanisms involved in these processes remain obscure. It is therefore important to pay more attention to the further investigation of the relevance between C. sinensis infection and bile duct carcinoma. This review summarizes the possible mechanism of cholangiocarcinoma caused by C. sinensis， which is displayed on mechanical damage， stimulation of the worms and their excretory-secretory products（ESP）， abnormity of immunoreaction and molecular genetic lesions.