氧化应激是机体内一种有害的氧化还原失衡状态,氧化应激是导致疾病的重要因素之一。肠道作为最易受氧自由基攻击的器官,研究肠道氧化应激机理与寻找预防和修复肠道氧化损伤的方法对发挥肠道机能有重要意义。实验证明抗氧化剂可以显着降低肠道氧化应激水平,目前许多抗氧化剂已经用于肠道氧化损伤的干预研究,本文将对动物肠道氧化损伤的机制及抗氧化剂的干预作用做一综述。
Oxidative stress is defined as a serious imbalance between the production of reactive species and antioxidant defenses,leading to potential tissue damage.Intestinal tract is one of the most vulnerable organs to free radical,so it is significant for the performance of gut to study the mechanism and intervention of oxidative stress in intestinal tract.Many antioxidants have been proved to alleviate the oxidative stress in gut.This article reviewed advance in the mechanism of the oxidative stress in intestinal tract and in the intervention of the antioxidants.