中文摘要：

本研究以脂多糖（LPS）作为自由基的诱发剂，微生物源性抗氧化剂作为自由基的清除剂，探讨自由基对大鼠繁殖性能的损伤及抗氧化剂的修复作用。将64只70日龄SD大鼠随机分成4组．每组16只。雌雄对半。对照组和损伤模型组饲喂基础日粮，抗氧化剂组和损伤修复组饲喂基础日粮并添加0．8mL／d·只微生物源性抗氧化剂。损伤模型组和损伤修复组腹腔注射1mg／kgLPS，对照组和抗氧化剂组注射等量的生理盐水，研究微生物源性抗氧化剂对雌鼠和雄鼠繁殖性能的影响。结果表明，注射LPS的雌鼠雌二醇浓度下降，受孕率降低，雄鼠精子数目、精子活动率和a级精子数显著降低。日粮中添加微生物源性抗氧化剂使雌鼠生育综合指数明显提高，血清中雌二醇含量升高。雄鼠精子数目增加，精子运动能力增强，断奶时仔鼠的数量和存活率提高。与损伤模型组相比，损伤修复组可一定程度提高大鼠的生育状况。结果提示，注射LPS导致大鼠产生氧化应激，对机体生殖机能造成损伤．微生物源性抗氧化剂具有提高大鼠繁殖性能并一定程度修复繁殖损伤的作用。

英文摘要：

The objective of this study was to investigate the effects of microbe-derived antioxidants on reproductive performance and repair function in rats using lipopolysaccharide （LPS） as free radicals inducer and microbe-derived an- tioxidants as free radicals scavenger.Sixty four 70-day-old SD rats were randomly divided into 4 groups with 16 replicates of each.Control group and damage model group were fed the basal diet,antioxidant group and repair group were fed the basal diet supplemented with 0.8 mL/d microbe-derived antioxidants.Model and repair group were injected 1 mg/kg body LPS through intraperitoneal injection, and control and antioxidant group were injected equivalent normal saline.The results showed that compared with control group,the concentration of estradiol and gestation rate decreased in female rats which were injected LPS,and sperm count,sperm motility and a class spermatozoa was obviously reduced in male rats in damage model group.In antioxidant group, antioxidant supplementation could significantly improve the reproductive coefficient and estradiol concentration of female rats,increase the survival rate and total litter numbers of weaning rats and enhance sperm amount and sperm motility of male rats.Compared with model group,repair group supplemented with microbe-derived an- tioxidants could improve fertility of rats.h was indicated that LPS could induce oxidative stress damage and decrease re- productive performance in rats ,and microbe-derived antioxidants could improve reproductive performance and had the functions of repairing damage to a certain extent.