中文摘要：

目的 探讨克罗恩病并发十二指肠内瘘的外科治疗方法.方法 回顾性分析2002年1月至2014年1月南京军区南京总医院收治的1 012例克罗恩病患者的临床资料,其中22例并发十二指肠内瘘.22例患者中12例十二指肠-回结肠吻合口瘘,7例十二指肠-横结肠瘘,2例十二指肠-乙状结肠瘘,1例十二指肠-小肠瘘.通过放置鼻肠管越过十二指肠内瘘行肠内营养支持,待营养状况及BMI、Alb、C反应蛋白、红细胞沉降率、克罗恩病活动指数评分等指标恢复正常或显著改善后行手术治疗.手术方式为十二指肠瘘修补术＋原发病灶肠管切除术.通过门诊、电话及网络形式随访,随访时间截至2014年5月.营养支持治疗前后比较采用t检验,非正态数据采用Mann-Whitney u检验.结果 2例患者因腹腔感染、1例患者因消化道出血行急诊手术,其余19例患者均先建立肠内营养途径.3例急诊手术患者行肠造口术,术后2例出现十二指肠修补处瘘（1例经肠内营养＋冲洗引流12d后愈合、1例再次手术治疗后痊愈）.19例患者经营养支持治疗肠内营养能量供应为（25.3 ±2.1）cal/g、肠内肠外营养能量供应为（28.5±3.2） cal/g,营养支持治疗时间为（31±5）d,C反应蛋白、克罗恩病活动指数评分由入院前25 mg/L、（207±111）分降至2 mg/L、（117 ±71）分,治疗前后比较,差异有统计学意义（u=53.000,t=0.942,P＜0.05）.BMI、Alb、红细胞沉降率治疗前分别为（17.0 ±2.1）kg/m2、（35±5） g/L、26 mm/h,治疗后为（17.9±2.8）kg/m2、（38±5）g/L、23 mm/h,治疗前后比较,差异无统计学意义（t=0.482,1.170,u=67.500,P＞0.05）.19例患者中1例经肠内营养治疗后内瘘消失,避免了手术;其余18例患者中5例行肠造口术,13例行肠吻合术.22例患者均获得随访.平均随访时间为13.4个月（4.0～37.0）个月,1例患者术后6个月吻合口复发致十二指肠-回结肠吻合口瘘,再次行手术治疗,其余均?

英文摘要：

Objective To investigate the surgical management of Crohn’s disease complicated with duodenal fistula.Methods The clinical data of 1 012 patients with Crohn’s disease who were admitted to the Nanjing General Hospital of Nanjing Military Connnand from January 2002 to January 2014 were retrospectively analyzed.Of the 1 012 patients,22 were complicated with duodenal fistula,including 12 with ileocolonic anastomosis-duodenal fistula,7 with colo-duodenal fistula,2 with sigmoido-duodenal fistula and 1 with duodeno-enteric fistula.All patients received duodenal fistula repair ＋ resection of diseased intestine.Patients were followed up via out-patient examination,phone call and email till May 2014.The condition of patients before and after enteral nutrition support was compared using the t test.Non-normal data were analyzed using the Mann-Whitney u test.Results Two patients with abdominal infection and 1 with gastrointestinal bleeding received emergent operation,and the other 19 patients received enteral nutrition support prior to operation.Three patients received emergent colostomy.Two patients had fistula at the duodenal anastomosis,and 1 patient was cured by enteral nutrition support ＋ drainage for 12 days and the other 1 received reoperation.The energies provided by enteral nutrition and enteral ＋ parenteral nutrition were （25.3 ± 2.1） cal/g and （28.5 ± 3.2） cal/g,respectively,and the time for nutrition support was （31 ± 5）days.The level of C-reaction protein and Crohn’s disease activity index were decreased from 25 mg/L and 207 ± 111 before treatment to 2 mg/L and 117 ± 71 after treatment,with significant difference （u =53.000,t =0.942,P 〈 0.05）.The levels of body mass index,albumin and blood sedimentation rate were （17.0 ± 2.1） kg/m2,（35 ± 5） g/L and 26 mm/h before treatment,and （17.9 ± 2.8） kg/m2,（38 ± 5） g/L and 23 mm/h after treatment,with no significant differences （t =0.482,1.170,u =67.500,P 〉 0.05）.One patient was cured by enternal nutrition.Five pa