中文摘要：

目的观察癫痫患儿的稳态卡马西平血药浓度与疗效及安全性的相关性。方法以病房和门诊癫痫患儿为研究对象，考察癫痫患儿卡马西平血药浓度与疗效及不良反应的相关性。结果癫痫患儿的卡马西平稳态血药浓度差异较大，86．7％的患儿血药浓度在治疗窗内，显效率并未随着浓度的升高而增加。药物不良反应以肝功异常为主，随血药浓度升高，不良反应有增加的趋势。结论应根据患儿血药浓度检测结果及时调整给药剂量，将血药浓度控制在有效浓度范围内。

英文摘要：

Objective To explore the correlation of efficacy and safety with the blood drug concentration of carbamazepine （CBZ） in epilepsy childrenin in north -east area. Methods Nine hundreds thirteen epilepsy children received normal - dose CBZ treatment were involved in this study. The efficacy and adverse drug reaction （ADR） were monitored to evaluate the remedy safety. Results CBZ steady concentration in serum had great imparity among individuals and 86.7% was in therapeutic windows. After arriving at effective concentration, efficacy wasn＇t increased with blood drug concentration. The main ADR were abnormal liver function and increased with blood drug concentration. Conclusion In clinic, it＇s necessary to determine individual remedy by serum concentration monitoring for adjust CBZ dosage in therapeutic window and decrease ADR.