中文摘要：

目的研究中国东北地区汉族癫痫患者HLA-B＊1502等位基因分布的频率。方法用聚合酶链反应DNA序列分析法,对125例中国东北地区汉族癫痫患者DNA标本进行HLA-B基因分型。结果 125例DNA标本中,共检测出34种不同的HLA-B等位基因。其中,2例患者携带HLA-B＊1502等位基因。HLA-B＊1502等位基因在中国东北地区癫痫患者中的分布频率为1.6%。其他分布频率较高的等位基因分别为HLA-B＊4001、B＊4601、B＊4801、B＊1302和B＊4002。结论东北地区癫痫患者中HLA-B＊1502等位基因分布频率（1.6%）与其在北京地区健康汉族人群中的分布频率近似（1.5%）;但远低于其在中国中部、西部及南部地区的分布频率。

英文摘要：

Objective To study the distributed frequency of the allele of HLA - B ＊ 1502 in Han ethnic epilepsy patients living in northeastern region of China. Methods The polymerase chain reaction sequence - based typing method was used to detect the genotype of HLA - B ＊ 1502 of all 125 epilepsy patients. Results Among all 125 epilepsy patients, there are 34 different types of alleles and only 2 patients with positive HLA - B ＊ 1502. The distributed frequency of the allele of HLA - B ＊ 1502 in Han ethnic epilepsy patients living in northeastern region of China is 1.6 %. The other main alleles with high distributed frequencies are HLA - B ＊ 4001, B ＊ 4601, B ＊ 4801, B ＊ 1302and B ＊ 4002, respectively. Conclusion The distributed frequency of HLA - B ＊ 1502 of Han ethnic epilepsy patients living in northeastern region of China is very similar to that in Beijing, which is far lower than that in central, western and southern regions of China.