中文摘要：

款冬花为菊科植物款冬Tussilago farfara的干燥花蕾,是中医临床和中药工业常用中药之一,主要含有倍半萜、三萜、黄酮、酚酸、生物碱等化学成分。其中,倍半萜是款冬花的特征成分,《中国药典》2015年版收载的质量评价指标即为倍半萜类成分款冬酮。款冬花中的倍半萜以bisabolane和oplopane骨架为主,已报道的倍半萜具有广泛的药理活性,包括抗炎、抗过敏、抗癌、神经保护、抑制血小板活化因子等。对款冬花中的倍半萜类成分的结构和生物活性进行综述,为款冬花的深入研究及开发利用提供参考。

英文摘要：

Farfarae Flos（FF） is derived from the flower buds of Tussilago farfara, and belongs to the Compositae family. It is one of the commonly used herbal drugs in the clinic and industry of Chinese materia medica. FF contained a series of chemical components, such as sesquiterpenes, triterpenes, flavonoids, phenolic acid, and pyrrolizidine alkaloids. Sesquiterpenes are present as the characteristic components in FF, and the quality evaluation indicator is tussilagone in Chinese Pharmacopoeia. Bisabolane and oplopane are the main skeletons for sesquiterpenes in FF, and the reported sesquiterpenes possessed a series of pharmacological properties, such as anti-inflammatory, anti-allergic, anticancer, neuroprotection, and platelet activating factor inhibition. This paper summarizes the chemical structures and biological activities of sesquiterpenes in FF, and provides the scientific basis for the further development and utilization.