中文摘要：

目的观察2型糖尿病颈动脉硬化患者血清胱抑素C水平。方法 282例2型糖尿病患者,按颈动脉内中膜厚度分为无颈动脉硬化组（A组,颈动脉内中膜厚度〈1.0 mm）和颈动脉硬化组,并进一步将颈动脉硬化组分为B组（颈动脉内中膜厚度≥1.0 mm）、C组（颈动脉内中膜厚度≥1.5 mm）,比较三组血清胱抑素C水平。结果 A、B、C组分别为90、93、99例,胱抑素C分别为（0.88±0.18）、（1.02±0.16）、（1.21±0.34）μmol/L,三组比较,P〈0.01。Logistic逐步回归分析发现,胱抑素C水平（OR=39.543,95%CI：1.608~972.513,P=0.024）与颈动脉内中膜厚度有关。结论 2型糖尿病颈动脉硬化患者血清胱抑素C水平升高,胱抑素C为颈动脉硬化的危险因素。

英文摘要：

Objective To observe the serum level of cystatin C in type 2 diabetic patients with carotid atherosclerosis.Methods We collected 282 cases of inpatients with type 2 diabetes mellitus. According to the carotid intima-media thickness（ CIMT）,they were divided into the normal group（ group A,CIMT 1.0 mm） and carotid atherosclerosis group,and further more the carotid atherosclerosis group was divided into group B（ CIMT ≥ 1. 0 mm） and group C（ CIMT ≥ 1. 5 mm）. We compared the serum levels of cystatin C in the three groups. Results There were 90,93 and 99 cases in the group A,B and C,and the levels of cystatin C were（ 0. 88 ± 0. 18）,（ 1. 02 ± 0. 16） and（ 1. 21 ± 0. 34） μmol / L. There was significant difference in these three groups（ P 0. 01）. Binary logistic stepwise regression analysis showed the serum cystatin C level（ OR = 39. 543,95% CI： 1. 608-972. 513,P = 0. 024） was related with CIMT. Conclusion The serum level of cystatin C increases in the type 2diabetic patients with carotid atherosclerosis and cystatin C is a risk factor for carotid atherosclerosis.