中文摘要：

背景：骨髓间充质干细胞在癌性微环境中的遗传稳定性问题如何进一步明确并加以有效预防，日益成为推广其临床应用的关键问题。非可控性炎症和肿瘤之间存在互为因果现象，越来越受到科学界关注。目的：分析骨髓间质干细胞在肿瘤微环境中的炎性信号通路及遗传稳定性的变化，并基于中医学温阳固肾、益气升阳、扶正祛邪理论为指导，探讨温阳益气法提高骨髓间质干细胞在肿瘤相关炎性微环境中的效应及其作用机制。方法：以“骨髓间充质干细胞，炎性平衡，补肾，温阳，益气，升阳，肿瘤，癌，阳化气，阴成形，遗传稳定性”为中文检索词，以“bone marrow mesenchymal stem cel s, inflammatory balance, replenishing qi, warming yang, strengthening shen, elevate yang, tumor, cancer, yang can transform qi, yin shaping up body, genetic stability”为英文检索词，应用计算机检索中国知网CNKI数据库、维普和PubMed数据库，严格按纳入标准、排除标准进行文献质量评估和筛选，最终选择42篇文献进行综合分析。结果与结论：在理化因素诱导或肿瘤微环境中，骨髓间充质干细胞可促进肿瘤增殖、侵袭转移，另外骨髓间充质干细胞自身也可被诱发转化为肿瘤相关纤维母细胞，发生遗传稳定性改变。炎性微环境及其骨髓间充质干细胞炎性信号通路异常在骨髓间充质干细胞的遗传稳定性改变中发挥重要作用，基于中医学温阳固肾、益气升阳、扶正祛邪理论，发现温阳益气类中药可明显提高肿瘤微环境及化学癌环境中骨髓间充质干细胞的遗传稳定性。

英文摘要：

BACKGROUND：How to further definite and prevent the genetic instability of bone marrow mesenchymal stem cel s in tumor microenvironment has increasingly become a key problem for its clinic application. Meanwhile, increasing studies focus on the reciprocal causation relationship between uncontrol ed inflammation and tumors. OBJECTIVE：To analyze the changes of inflammation-related signaling pathways and genetic stability in bone marrow mesenchymal stem cel s under the tumor microenvironment, and meanwhile, to investigate the influence and mechanism of“warming yang and benefiting qi”method on inflammatory signaling pathways and the genetic stability of bone marrow mesenchymal stem cel s in tumor microenvironment, based on the guidance of the traditional Chinese Medicine theories“warming yang and tonifying kidney, benefiting qi and raising yang, strengthening healthy and discarding evil to eliminate pathogens”. METHODS：A computer-based online search of PubMed, CNKI and VIP was performed for relevant articles with the keywords of“bone marrow mesenchymal stem cel s, inflammatory balance, replenishing qi, warming yang, strengthening shen, elevate yang, tumor, cancer, yang can transform qi, yin shaping up body, genetic stability”in English and Chinese, respectively. Screened literatures were evaluated strictly according to the inclusion and exclusion criteria, and final y 42 articles were included in result analysis. RESULTS AND CONCLUSION：Under physical and chemical induction or tumor microenvironment, bone marrow mesenchymal stem cel s can promote tumor proliferation, invasion and metastasis. In addition, bone marrow mesenchymal stem cel s can be induced to differentiate into malignant cel s or tumor associating fibroblasts, fol owed by genetic instability, in tumor microenvironment. Inflammatory microenvironment plays an important role in regulating inflammation-related signals and genetic stability of bone marrow mesenchymal stem cel s. Chinese traditional medicines functioning as“warming yang an