中文摘要：

目的探讨Fratl在肺癌组织中的表达情况以及Fratl与β-catenin在肺癌组织中表达的相关性。方法用免疫组化SP法对115例原发性非小细胞肺癌（NSCLC）患者手术标本中Fratl和β-catenin的表达进行检测，使用SPSS16．0统计软件进行分析。结果在NSCLC中，Fratl的表达与肺癌组织的低分化（P=0．035）、淋巴结转移（P=0．019）、TNM分期相关（P=0．010）；β-catenin的表达与肺癌组织的低分化（P=0．017）、淋巴结转移（P=0．007）、TNM分期相关（P=0．016）；Fratl的表达与β-catenin的表达有相关性（P=0．003）。结论Fratl和β-catenin与肺癌的低分化、转移、高级别TNM分期等恶性表型有关，二者在肺癌组织中的表达有相关性，Fratl可能成为NSCLC患者靶向治疗的新靶点。

英文摘要：

Objective To investigate the coexpression among Fratl and β-catenin and the significance. Methods Immunohisto- chemistry was performed on 115 cases of non-small cell lung cancer （NSCLC）. The correlations between expressions of Fratl and β-catenin was analyzed. Results Immunohistochemistry results showed that Fratl was related to tumor differentiation, TNM stage, and lymph node metastasis （ P 〈 0. 05 ） ; β-catenin was related to tumor differentiation, TNM stage, and lymph node metastasis （ P 〈 0. 05 ） ; Fratl and β-cate- nin were coexpressed in lung cancer tissues （P 〈0. 05 ）. Conclusions Fratl and β-catenin expression are associated with malignant pheno- type of lung cancer; Fratl and β-catenin coexpression in lung cancer tissues, Fratl may become the target new therapeutic target in patients with non-small cell lung cancer.