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中文摘要：
异常朊蛋白（PrPsc）是一种可引起人和动物传染性脑退化病的不含核酸的蛋白因子。PrPsc是一个正常的蛋白，有正常的生理功能，主要分布于神经元表面，属于肌醇磷脂锚蛋白类。由PrPc向PrPsc转变即产生疾病。作者简单介绍了正常和异常朊蛋白结构、功能、构象改变及朊病毒种属屏障的研究进展，并提出了目前尚待研究的问题；
英文摘要：
Prion was a protein which could cause the transmissible neurodcgencrative diease of human and animal, which did not include the nuclear. PrPc was normal protein which had normal foundation, contributing in the surface of neuron, belonging glycoinositol phospholipids. It was PrPc changed into PrPsc that cause these disease. This review introduced the advance of the structure, foundation, conformation changing of normal and non-normal prion protein and species barrier of prion, putting forward to the question be researched now.
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