中文摘要：

目的 探讨人端粒保护蛋白（human protection of telomeres，hPOT1）在胃癌中的异常表达及其临床意义。方法 用SP免疫组化方法检测hPOT1在57例胃癌标本中的表达，同时以10例正常胃黏膜标本做对照。结果 57例胃癌标本的表达全阳性，阳性率100％，显著高于正常胃黏膜hPOT1的表达（40％）。浸润至或超过浆膜层的胃癌hPOT1表达强度显著高于未达浆膜层者，Ⅲ／Ⅳ期胃癌明显高于Ⅰ/Ⅱ期胃癌，低分化胃癌高于高分化胃癌（P〈0．05）。结论 hPOT1在胃癌组织中表达异常增高，提示hPOT1与胃癌的发生、发展有密切的关系，检测hPOT1的表达可能会有助于胃癌的早期诊断和预后。

英文摘要：

Objective To study the abnormity of hPOT1 expression in gastric cancer and their clinical significance. Methods The expression of hPOT1 were detected in 57 gastric cancer specimens by SP immunohistoehemieal method, and 10 normal gastric mucosa was control. Results All 57 cases gastric cancer showed positive staining of hPOT1 （ 100 % ）, which was much higher than that in normal gastric mucosa（20 % ）. hPOT1 expression levels were significantly higher in tumor plasma membrane infiltration than in theose without infiltration, in stage Ⅲ/Ⅳ tumors than in stage Ⅰ/Ⅱ tumors, and in poorly differentiated tumors than in well-differentiated tumors （ P 〈 0.05）. Conclusion It indicates that hPOT1 may play an important role in the carcinogenesis of gastric cancer.