中文摘要：

目的：探讨5例罕见的双侧嗅裂区呼吸道上皮腺瘤样错构瘤（REAH）的临床病理特点。方法：结合文献复习,报告5例经病理证实的REAH患者。结果：4例以鼻塞,流涕为首要主诉,伴或不伴嗅觉减退、头痛,1例以头面部不适为首要主诉,偶有流脓涕及涕中带血。5例鼻腔中鼻道可见息肉样新生物。所有患者均行鼻窦内镜手术清除病灶,REAH病灶均位于双侧嗅裂区,4例外观呈息肉样改变,1例炎性水肿明显,均较息肉质韧,并且基底弥漫,内衬表面上皮源性纤毛呼吸上皮的腺体异常增生为REAH病理学特征,腺体围成圆形或椭圆形,大小不一,被一些间质组织所分隔。结论：REAH如果不彻底切除,有术后继续生长的可能性,故鼻内镜手术时,完全彻底清除病灶是手术成功的关键。尽管鼻腔鼻窦区域的REAH非常少见,但应与内翻乳头状瘤以及腺癌相鉴别。

英文摘要：

Objective：To describe five rare cases of bilateral olfactory clefts respiratory epithelial adenomatoid hamartoma（REAH）,and investigate the clinicopathologic features in REAH.Method：Five cases with REAH were reported and the relevant literatures were reviewed.All the cases were confirmed by pathology.Result：The chief complaint in 4 cases when visited was nasal obstruction and rhinorrhea,with or without hyposmia and headache.Another was discomfortable of head-facial region,sometimes with pus discharge and blood in nasal discharge.Polypoid neoplasms can be seen in nasal meatus of the 5 cases.Endoscopic sinus surgery was utilized to eliminate foci in 5 cases.All REAH foci located in bilateral olfactory clefts areas,four of which appeared polypoid changes,one appeared obvious inflammatory edema.All of them presented as wide-based lesion with tenacious quality compared to polyps.Histologically,these lesions were characterized by a glandular proliferation lined by ciliated respiratory epithelium originated from the surface epithelium,and the glands surround into round or oval,with various sizes and separated by stromal tissue.Conclusion：It is possible to continue developing after operation,if REAH is not completely resected.Complete resection of lesions is the key to treatment success for this entity in endoscopic sinus surgery.Although REAH arising from the rhinosinusal region is very rare,rhinolaryngologists must know this entity in order to differentiate it from inverted papilloma and adenocarcinoma.