中文摘要：

人类疾病的动物模型（AnimalModelofHumanDiseases）是生物医学科学研究中所建立的动物实验对象和材料。近年来，随着对动物模型的研究，各种人类疾病的实验模型得到广泛应用。酸性哺乳动物壳多糖酶（AMCase）作为壳多糖酶家族重要成员之一，与其下游信号分子嗜酸性粒细胞趋化因子（eotaxin．3）以及白细胞介素13（IL-3）的级联免疫反应，近年来成为了动物模型研究中的热点。本文总结了AMCase、eotaxin．3及IL-13在动物模型中的研究进展及其临床意义。

英文摘要：

Tanimal Model of human diseases is animal experiments objects and materials that used in biomedical science study. In recent years, with the research of animal models of human diseases, all kinds of experimental models widely used. Acid mammals chitinase （AMCase） as one important member of the chitinase family, and the downstream signal molecule eosinophils chemokine （eotaxin-3） and interleukin-13 （IL-13） cascade immune response, in recent years become a hot spot in the study of animal models. This article summarized the progress in study on AMCase, Eotaxin-3 and IL-13 in animal model, and their clinical significances.