中文摘要：

本文旨在了解高铜对肉鸡肾脏线粒体抗氧化功能的影响。选用1日龄科宝肉仔鸡120只，随机分成4组，分别喂以对照日粮（Cu 11mg／kg，对照组）和高铜日粮（Cu 110mg／kg，高铜Ⅰ组；Cu 220mg／kg，高铜Ⅱ组；Cu 330mg／kg，高铜Ⅲ组），检测梯度剂量硫酸铜在不同的饲喂时间（12日龄、24日龄、36日龄、48日龄、60日龄）肉鸡肾脏线粒体超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH—Px）、丙二醛（MDA）的指标。结果显示：高铜Ⅱ组与高铜Ⅲ组SOD、GSH—Px、MDA都呈现代偿性升高，然后有降低的趋势。提示日粮中铜浓度达到220mg／kg时，肾脏线粒体功能紊乱。

英文摘要：

The experiment was conducted with an objective to examine the effect of high dietary copper on the mitochondrial antioxidantal index of kidney cells. One hundred and twenty healthy 1 day-old Cobb broilers were randomly divided into four groups based on diets as follows： control（Cu 11 mg/kg）and high copper（Cu 110 mg/kg as high copper group Ⅰ ;Cu 220 mg/kg as high copper group Ⅱ ;Cu 330 mg/kg,high copper group Ⅲ ）. Kidney mitochondria was taken from broiler after killed per group at 12^th , 24^th, 36^th, 48^th and 60th days respectively. Kidney mitochondria was determined for measuring concentrations of SOD, GSH-PX,MDA. The results showed that SOD, GSH-PX, MDA in high copper group Ⅱ and high copper group m were compensatory increased and then decreased. The results indicate that 220 mg/kg of copper in diet can cause mitochondrial dysfunction in kidney cells.