中文摘要：

具有多向分化潜能的骨髓基质干细胞（BMSCs）为力学敏感细胞,在体外适当机械刺激作用下,其生物学特性会发生功能性改变,以达到力学刺激的最佳要求,并表现为成骨向分化。此过程涉及多条信号转导通路,但BMSCs如何将机械刺激转变为生物信号,进而指导体内骨形成和改建的确切机制仍不清楚。本文就机械刺激对体外骨髓基质干细胞骨向分化的影响及可能的作用机制等方面的研究进展作一综述。

英文摘要：

[Summary] Bone mesenchymal stem cells（BMSCs）,which are force-sensitive cells,have potentials for differentiation into cells of various types.Their biological characteristics can change functionally according to the appropriate stimulation in vitro,in order to reach the optimal demand of the stimulation.Many signal pathways are involved in osteogenesis.However,how BMSCs transform mechanical stimulation into biological signals and then instruct the bone formation and remodeling is still unclear.The exact mechanism remains to be studied further.This paper summarizes the recent research of effect and possible mechanism that mechanical stimulation acts on bone differentiation of BMSCs in vitro.