中文摘要：

目的 CD4^＋CD25^＋Foxp3^＋调节性T细胞（Treg）是肿瘤免疫抑制微环境的主要组成部分,其在肿瘤的免疫抑制微环境中分泌IL-10、IL-35、TGF-β1和FGL2等细胞因子发挥免疫抑制作用。Treg细胞抑制CD4^＋T、CD8^＋T淋巴细胞和NK细胞,进而抑制特异性抗肿瘤免疫反应使肿瘤细胞更容易逃避免疫监视。进一步研究Treg细胞在肿瘤免疫中的作用机制,对深入了解恶性肿瘤的发病机制及免疫治疗具有重要的理论意义。此外,Treg细胞及其分泌的细胞因子在肿瘤治疗和预后评估等方面也具有广阔的临床应用前景。

英文摘要：

CD4 ^＋ CD25 ^＋ Foxp3 ^＋ regulatory T cells（Tregs） are essential for tumor immunosuppressive microenvironment and secrete some inhibitory cytokines IL-10,IL- 35,TGF- β1 and FGL2 which are key mediators of Treg immunosuppressive function.Tregs have been shown to be important contributors to the tumor escape immunosurveillance and play a critical role in the induction of suppression to CD4^＋T,CD8 ^＋ T and NK cell,and suppression of specific anti- tumor immunity.Further research of the role of Tregs in tumor immunosuppressive microenvironment is important to understand malignant tumor pathogenetic and immunological therapeutics.In addition,Tregs and inhibitory cytokines become more critical for clinical applications,prognosis evaluation and therapies.