中文摘要：

目的：比较不同产地山茱萸中马钱苷的含量，考察山茱萸药材3年的稳定性和含果核多少对山茱萸中马钱苷含量的影响。方法：采用高效液相色谱梯度洗脱法对山茱萸中马钱苷进行含量测定。结果：马钱苷进样量在0．077376—4．8361xg范围内线性关系良好，平均加样回收率为97．9％，RSD=1．30％。结论：不同产地山茱萸药材中马钱苷含量在0．79％-0．92％范围内，药材中马钱苷含量在3年内稳定性良好。未去核山茱萸的马钱苷含量低于0．60％，其他16批山茱萸药材含马钱苷不少于0．60％。

英文摘要：

Objective：To compare the contents of loganin in Cornus officinalis from different distribution areas;study the quality stability of Comus officinalis for three years;research the effect of fruit stones to the content of loganin in Comus officinalis. Methods：The HPLC method was performed on Diamonsil C18 （4. 6 × 250mm ,5um）column by gradient elntion with a mixture liquid of acetonitrile and 0.05% （v/v） phosphoric acid in water. The detective wavelength was 240 nm. Results ：The calibration curve of lo- ganin was linear over the range of 0. 077376 -4. 836p, g,The average vecovery was 97. 9% with RSD 1.3 %. Conclusion：The con- tent of loganin in Comus officinalis from different distribution areas are among 0. 79% - 0. 92%. The quality stability of Comus officinalis for three years is good. The contents of loganin in Comus officinalis with fruit stones are less than 0. 60% ;the others are more than 0. 60%.