中文摘要：

肾细胞癌是常见的泌尿系统恶性肿瘤。既往肾细胞癌分类主要依赖于形态学,但日渐明晰的分子和遗传学改变将有助于更好地进行分类、治疗选择及预后评估。2012年在加拿大温哥华召开的国际泌尿病理学会（ISUP）共识会议,对肾肿瘤的组织学分类、分期、预后因素、免疫组化和分子标志物等领域的最新进展进行讨论并达成共识,亦将成为下一版WHO分类的基础。本文介绍常见肾细胞癌的病理诊断和研究进展,以及2012年ISUP共识分类中的肾细胞癌新类型的形态学特征、免疫组化标记、分子和遗传学改变。

英文摘要：

Renal cell carcinomas are common malignant tumors of the urinary system.Although current classification of renal cell neoplasms is mainly based on histological features,molecular and cytogenetic characterizations have been increasingly utilized to improve classification,treatment decisions,and prognosis.The 2012 Vancouver conference of the International Society of Urological Pathology（ISUP）has reached consensus in many aspects regarding classification,grading,staging and other prognostic factors,as well as molecular biomarkers of renal cell carcinoma.The consensus will form the basis of the next WHO classification of kidney tumors.This paper briefly reviews the histological diagnostic criteria and advances in research of common renal cell carcinomas,as well as the morphological,immunohistochemical,molecular and cytogenetic characteristics of new entities recognized by the 2012 ISUP consensus.