中文摘要：

目的报道2例膀胱原发透明细胞癌患者的资料,并进行相关的文献复习,探讨原发膀胱透明细胞癌的临床诊治方法。方法回顾性分析我院2012~2015年收治的2例膀胱原发透明癌患者临床资料,并结合文献复习讨论。结果 2例中1例发生于膀胱右侧壁近膀胱颈处,另一例肿瘤位于三角区,均以肉眼血尿就诊。病理上肿瘤组织均来源于腺癌,呈巢团状腺样排列,胞质丰富,淡染,核仁明显。免疫组化均示CK7（＋）、PAX8（＋）、CA125（＋）。1例行膀胱肿瘤电切术,15个月出现复发,遂行膀胱癌根治术,随访1年后死亡;1例因患者一般情况差行肿瘤电切术＋双侧输尿管腹壁造口,随访10个月后未见进展。结论膀胱透明细胞癌多以血尿为主要表现,多需要病理检查才能确诊,治疗以根治性手术为主,预后差于典型尿路上皮癌。

英文摘要：

Objective To investigate the clinical,pathological and histopathological features of primary bladder clear cell carcinoma and to explore its diagnosis and treatment.Methods The clinical and pathological features of 2 cases of primary bladder clear cell carcinoma were analyzed and relevant literatures were reviewed.Results Both patients complained of gross hematuria.In 1 case the tumor was located in the right wall of the bladder close to cervix vesicae,while in the other case the tumor was located in the triangle area.Both cases were confirmed to be clear cell carcinoma by preoperative biopsy.One case underwent transurethral electroresection,but the tumor recurred after 15 months.Radical cystectomy was performed,and the patient died 1 year after operation.The other case underwent TURBT plus cutaneous ureterostomy and was progress-free 10 months after operation.Conclusions Primary clear cell carcinoma of the bladder is a rare adenocarcinoma with hematuria as the main manifestation diagnosed by pathological study.The outcome of the disease is worse than common urotheliar carcinoma.