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测定氨咖黄敏胶囊3种成分含量的新方法
  • 时间:0
  • 分类:TQ460.7[化学工程—制药化工]
  • 作者机构:[1]佳木斯大学药学院,黑龙江佳木斯154007, [2]黑龙江省鹤岗市食品药品检测中心,黑龙江鹤岗154100, [3]黑龙江省生物药制剂重点实验室,黑龙江佳木斯154007
  • 相关基金:国家自然科学基金资助项目(51402092)
中文摘要:

建立高效液相色谱法( HPLC)“一测多评”法测定氨咖黄敏胶囊中3种有效成分的含量,以对乙酰氨基酚为内标物,建立该成分与咖啡因、马来酸氯苯那敏的相对校正因子并计算此3种成分的含量。同时采用外标法测定,两种测试结果无显著差异, RSD<0.78%,表明建立的“一测多评”法测定氨咖黄敏胶囊中的对乙酰氨基酚、咖啡因、马来酸氯苯那敏,准确可行。

英文摘要:

An HPLC-QAMS method was established for quantitative analysis on multi-components by single marker in analysis on Ankahuangmin capsule for the simultaneous determination of three main constituents . Using paracetamol as an index , the relative factors of caffeine and chlorphenamine maleate were established by HPLC , which was used to calculate the content .It shows no significant difference between the results of QAMS method and those external standard methods , RSD〈0.78%.It shows that this method is feasible and suitable which valuate the quality of paracetamol , caffeine and chlorphenamine maleate in Ankahuangmin capsule by QAMS .

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