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中文摘要：
癌症发病率和耐药性的不断攀升,促使新结构和新作用机制药物的发现更为迫切.近年来,特异生境微生物的化学成分和生物活性研究日益受到关注.本课题组通过对药用植物内生菌和海洋微生物的分离、筛选和系统的化学成分分离,获得了一些结构新颖复杂的活性天然产物,并对其中2个化合物的抗肿瘤作用机制进行了研究.这些结果表明特异生境微生物蕴含着丰富的新活性化学成分,值得深入发掘.
英文摘要：
The discovery of new anti-tumor drugs is a pressing and continual need for human health due to the constant emergence of drug resistant tumor cell lines, and the rising occurrence of cancer. In recent years, researchers are paying more and more attention to the chemical components of microorganisms isolated from specific habitats and their bioactivities. Our group isolated a large number of new bioactive natural products, most with complex structures, from endophytes of medicinal plants and marine microbes. Moreover, the antiturnor mechnisms and targets of two classes of compounds were investigated. Our results indicated that these special microbes are of great potential for new bioactive compounds and deserve further ex- plorations.
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Chemical Constituents of the Endophytic Fungal Strain Phomopsis sp. NXZ-05 of Camptotheca acuminata.
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Endophytic fungi from a pharmaceutical plant, Camptotheca acuminata: isolation, identification and b
Unusual Activities of the Thioesterase Domain for the Biosynthesis of the Polycyclic Tetramate Macro
Identification and Characterization of the Anti-Methicillin-Resistant Staphylococcus aureus WAP-8294
Chemical Components of Some Microorganisms Isolated from Specific Habitats and Their Antitumor Activ
Hsp90 interacts with AMPK and mediates acetyl-CoA carboxylase phosphorylation , 2012, 24(4):859-865.
Mycoepoxydiene, a fungal polyketide inhibits MCF-7 cells through simultaneously targeting p53 and NF
Mycoepoxydiene Inhibits Lipopolysaccharide-Induced Inflammatory Responses through the of TRAF6 Polyu
Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in He
New chemical constituents from the endophyte Streptomyces sp. LR4612 cultivated on Maytenus hookeri.
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