中文摘要：

目的研究肝毒性吡咯里西啶类生物碱千里光碱的大鼠体内代谢。方法SD大鼠口服千里光碱，收集胆汁、尿液及粪便样本，采用液相色谱一多级质谱联用对代谢产物进行研究，推导其体内代谢模式。结果正负离子下共检测到38种代谢产物，主要为千里光碱及其代谢物的氯氧化物，羟化产物，水解产物，以及硫酸结合物，葡萄糖醛酸结合物和谷胱甘肽结合物。另外，尿液、胆汁与粪便中检测到的代谢物有一定差异，胆汁和尿液中代谢产物较多。结论千里光碱在大鼠体内代谢广泛，形成多种代谢产物。

英文摘要：

OBJECTIVE To investigate the metabolic profile of senecionine in rats. METHODS Liquid chromatography-tandem mass spectrometry（LC-MSn） mass spectrometry was used for the analysis of senecionine and its metabolites in rats bile, urine, and feces after a single oral dose of senecionine. RESULTS In total 38 metabolites were identified, including oxidation products, by-droxylation products, hydrolysis products, sulfation products, glucuronidation products, and GSH-conjugations. And metabolites were found to be more abundant in bile and urine than those in feces. CONCLUSION Senecionine undergoes extensive metabolism in rats.