乳腺癌是女性常见的恶性肿瘤,乳腺癌的诊断、治疗及预后与其细胞凋亡密切相关。本文对国内外有关药物诱导乳腺癌细胞凋亡的作用机制如药物对细胞周期、线粒体膜电位、细胞内钙离子浓度及caspase家族的影响等内容进行概述,试图为抗乳腺癌新药物的研发找到新的途径。
Breast cancer is a common malignant tumor in women. Apoptosis is related to the response and resistance to treatment in breast cancer. This paper timber summarize the research progress on the mechanisms of drug-induced apoptosis in breast cancer cells, effects of cell cycle, mitochondrial membrane potential, intracellular calcium concentration and caspase families, and attempts to find new strategies for anticancer efficacy of new drug.