中文摘要：

HAART明显降低了儿童HIV相关疾病的发病率及病死率，在预防母婴传播中起到了非常重要的作用。由于HIV感染儿童将面临一生的抗病毒治疗，药物相关的线粒体毒性问题日益受到重视。此文对儿童抗病毒治疗所致线粒体毒性的临床表现、发病机制及相关临床和实验室研究等进行了综述。

英文摘要：

Highly active anti-retrovirus therapy （HAART） has resulted in a substantial reduction in paediatric HIV-associated mortality and morbidity and mother-to-child transmission. However, it is inevitable that children with HIV infection will be exposed to HAART for an ever-increasing length of time throughout their lives, and the cumulative toxicities of HAART are becoming progressively apparent. This review is to summarize the most recent work and provide an overview to the clinical manifestations and pathogenesis of mitochondrial toxicity resulted from paediatric HAART.