中文摘要：

针对现有医用敷料吸收渗液能力不强等缺点,以海洋蟹虾外壳中提取的壳聚糖和蚕丝加工过程废弃的丝胶蛋白为主要原料,研制出一种新型生物流体材料。该材料为黄褐色半透明、半流动物质,能形成柔韧透明的薄膜从而起到防感染的天然屏障作用。通过改变壳聚糖与丝胶蛋白的配比,可以有效调控壳聚糖/丝胶蛋白生物流体材料膜的吸液能力和通透性等,其吸水量、水蒸汽透过率分别分布在2.33～23.73 g/g和2 738～3 752 g/（m2.d）之间,可以满足不同程度创面修复需要。虽然添加丝胶蛋白使生物流体材料膜的力学性能稍有降低,但仍具有医用敷料要求的较高柔韧性。体外抗菌试验表明,该流体材料膜的抑菌率随着丝胶蛋白含量增加而有所降低,但当壳聚糖与丝胶蛋白质量比为1∶0.6时,对金黄色葡萄球菌（Staph-ylococcus aureus）的抑制率仍高达83%,能有效预防创面感染,具有临床应用前景。

英文摘要：

To overcome the limitation of commercial wound dressings with poor fluid absorption capability,a novel chitosan/sericin biological fluid material was successfully prepared by using chitosan extracted from shells of sea crabs and sericin discarded as waste material in silk industry as the major materials.The unique biological material was tawny,semitransparent and semi-fluid.It could form soft and transparent film,functioning as a natural barrier against infection.Its fluid absorption capability and permeability could be adjusted by changing the ratio of chitosan to sericin.Its moist absorption capability and water vapor permeability was in the range of 2.33~23.73 g/g and 2 738~3 752 g/（m2·d） respectively,being able to satisfy the needs in healing various wounds.The mechanical property of resultant film slightly reduced after addition of sericin,but it still kept excellent flexibility to satisfy clinical demand of wound dressing.In vitro antibacterial experiment indicated that,although the addition of sericin reduced antibacterial activity of the fluid material,its antibacterial rate was as high as 83% against Staphylococcus aureus when the mass ratio of chitosan to sericin was 1 ∶0.6,being able to prevent wound infection effectively.These results indicate that the novel chitosan/sericin biological fluid materials have good perspective in clinical application.