中文摘要：

目的探讨超声辐照对离体兔全血黏度的影响及安全性，为临床应用超声辐照改善血液流变状态提供实验基础。方法20只健康新西兰大白兔，每只取全血50ml，随机分为5组，1组为对照组，其余4组均以频率0．87MHz的超声波连续辐照，声强及辐照时间分别为2W／cm2×1min、3w／cm2×1min、4w／cm2×1min、4W／cm2×3min，随后对5组血样行血细胞计数，血黏度检测及白细胞吞墨试验。结果3W／cm2组与对照组比较血细胞计数及粒细胞吞墨率无差异，低切全血表观黏度1、红细胞聚集指数分别下降7．76％，6．24％（P〈0．05）；4W／cm2×1min组与对照组比较血小板下降8．24％（P〈0．05），粒细胞吞墨率下降明显，血黏度进一步下降（P〈O．05）；2w／cm2组及4W／cm2×3min组与对照组比较血黏度无显著差异。结论超声辐照能改善离体兔全血的流变特性，选择3w／cm2×1min超声辐照，可在不影响血细胞形态及功能的前提下改善离体血液流变状态。

英文摘要：

Objective To study effects and safety of ultrasound irradiation in blood viscosity in vitro rabbit, pro- viding experimental basis for its clinical application. Methods 50 ml blood sample from 20 healthy New Zealand rab- bits, were divided into five groups randomly, including one control group and four irradiation groups, which were irra- diated by 0.87 MHz ultrasonic beams under 2 W/cm2 ×1 min,3 W/cm2 × 1 min, 4 W/cm2 × 1 min and 4 W/cm2 × 3 min separately. Then all blood sample of the five groups were analyzed for blood viscosity, blood cell counts and ink- phagocytizing of leukocyte. Results Compared to those in the control, the counts of blood corpuscle had no significant difference in 3 W/cmz group, while the counts of platelet decreased significantly in the 4 W/cm2×1 min group（P〈 0.05）, Compared to those in the control, the value of whole blood apparent viscosity η erythrocyte aggregation index in 3 W/cm2 group had a significant decrease separately in7. 76%, 6. 24% （P〈0.05）. The value of blood viscosity de- creased more in the 4 W/cm2 ×1min group than that in the 3 W/cm2 group（P〈0.05）, In the succeeding ink-phagocy- tizing of leukocyte tests, it demonstrated that no difference between the 3 W/cm2 group and the control. Conelusions Ultrasonic irradiation can improve the in-vitro hemorrheology with hemolytic risk, and the study indicated irradiation under 3 W/cm2 X 1 min as an efficient and safe parameter.