中文摘要：

目的观察肝豆状核变性（Wilson＇s disease,WD）患者不同中医证型的血尿酸水平、Goldstein分级及其两者的关系。方法将符合纳入标准的906例WD患者根据不同中医证候分为痰蒙心窍组（26例）、痰火扰心组（90例）、湿热内蕴组（113例）、气血两虚组（168例）、肝肾阴虚组（327例）、肝肾亏虚组（182例）。以同期年龄相仿、饮食结构大致相同的160例健康体检者作为正常对照组。分别于清晨空腹采肘正中静脉血检测各组血尿酸水平。结果 WD各中医证型组血尿酸水平[痰蒙心窍组为（146.08±67.24）μmol/L、痰火扰心组为（157.08±69.77）μmol/L、湿热内蕴组为（162.58±97.72）μmol/L、气血两虚组为（156.20±62.63）μmol/L、肝肾阴虚组为（161.83±111.23）μmol/L、肝肾亏虚组为（194.41±90.01）μmol/L]均较正常对照组[（242.39±87.55）μmol/L]明显降低（P〈0.01）。各中医证型组间比较发现,肝肾亏虚组血尿酸较痰蒙心窃组、痰火扰心组、湿热内蕴组、气血两虚组、肝肾阴虚组升高（P〈0.01）。Goldstein分级结合血尿酸分析发现,随着Goldstein分级的增加（即病情的加重）,患者血尿酸水平下降（P〈0.01）。结论 WD患者血尿酸水平较减健康人降低,不同中医辨证分型血尿酸水平及Goldstein评分不同;且血尿酸具有评定患者病情轻重的价值。

英文摘要：

Objective To observe blood uric acid levels and Goldstein grading,as well as their correlation in Wilson＇s disease（WD） patients with different Chinese medical syndrome types.Methods Totally 906 WD patients in line with inclusive criteria were assigned to 6 groups,i.e.,the heart spirit confused by phlegm group（HSCP,26 cases）,the phlegm-fire disturbing heart group（PFDH,90 cases）,the retention of damp-heat group（RDH,113 cases）,deficiency of qi and blood group（DQB,168 cases）,the deficiency of Gan-yin and Shen-yin group（DGYSY,327 cases）,the deficiency of Gan and Shen group（DGS,182 cases） due to different Chinese medical syndrome types.Recruited were another160 healthy subjects having similar ages and diet structures,who came for medical examinations,as the healthy control group.Venous blood was collected from the medial cubital vein of each patient on an empty stomach in early mornings to detect blood uric acid levels.Results Blood uric acid levels were lower in each syndrome type group than in the healthy control group（146.08 ±67.24 ｜xmol/L in the HSCP group;157.08 ±69.77 μmol/L in the PFDH group;162.58 ±97.72 μmol/L in the RDH group;156.20 ±62.63 μmol/L in the DQB group;161.83 ±111.23 μmol/L in the DGYSY group;194.41 ±90.01 jjimol/L in the DGS group;242.39 ±87.55 μmol/L in the healthy control group,P 0.01）.Blood uric acid levels were higher in the DGYSY group than in the other 5 syndrome groups（P 0.01）.Correlation analyses between Goldstein grading and blood uric acid showed that,along with increased Goldstein grade（that was aggravating disease conditions）,WD patients＇ blood uric acid levels decreased（P 0.01）.Conclusions WD patient＇s blood uric acid levels decreased more.Blood uric acid levels and Goldstein grading were different in various Chinese medical syndrome types.Blood uric acid levels had certain value in assessing the severity of WD.