中文摘要：

目的：探讨基质金属蛋白酶-3（MMP-3）在骨性关节炎（OA）患者不同病变程度滑膜中的表达及意义。方法：应用免疫组化检测MMP-3蛋白在90例关节炎组[关节炎组，又依据Kellgren和LawrenceX线诊断标准分为：I级为第一亚组（轻度病变组，30例），Ⅱ、Ⅲ级为第二亚组（中度病变组，30例），Ⅳ级为第三亚组（重度病变组，30例）]与30例对照组患者滑膜组织中的表达情况。结果：MMP-3在所有滑膜组织中都能检测到。与对照组比较，MMP-3在关节炎组中的含量上升（P〈0．05）。重度病变组MMP-3的表达水平与轻度病变组、中度病变组比较，差异有统计学意义（P〈0．05）；OA的严重程度与MMP．3的表达水平呈正相关（r=0．912，P〈0．05）。结论：MMP-3蛋白与OA的致病机制密切相关，可能作为OA早期诊断和病情活动性的一项重要指标。

英文摘要：

Objective To investigate the expression and significance of MMP-3 in knee joint synovium of different stage in osteoarthrifis （OA） patients. Methods MMP-3 protein were detected by immunohistochemical method in knee synovial tissues from 90 OA patients （the OA group） and OA group was divided into 3 subgroups according to Kellgren and LawrenceX-ray diagnosing standards： the grade I （n = 30）, gradeII （n = 30） and grade m subgroups （n = 30）. 30 patients were enrolled as control group. Immunohistochemistry was used to detect the expression of MMP-3 protein in the tissue. Results The expression level of MMP-3 protein in OA group was significantly higher that in the normal synovium （P 〈 0.05 ）. There existed significant difference in the expression of MMP-3 protein between the grade m subgroup and the grade I , orII subgroups （P 〈 0.05）. The expression of MMP-3 protein related positively to the severity of OA （r = 0.912, P 〈 0.05）. Conclusion The expression of MMP-3 protein related closely to the pathogenic mechanism of OA. It may serve as an important indicator of early diagnosis and the activity of OA.