目的:探讨胰腺癌和其它胰腺肿瘤组织中淋巴管密度的差异及意义。方法:应用免疫组化方法,采用单克隆抗体D2-40检测经手术切除的33例胰腺癌(PC)、7例胰腺神经内分泌肿瘤(NETP)、7例胰腺实性假乳头状瘤(SPTP)和3例胰腺囊腺瘤(CP)组织的淋巴管密度(LVD),比较胰腺癌组织与其它三种胰腺肿瘤组织淋巴管密度的差异。结果:NETP的LVD显著高于PC、SPTP、CP(P〈0.05),PC的LVD显著高于SPTP、CP(P〈0.05),SPTP和CP的LVD没有差异(P〉0.05)。结论:胰腺癌和胰腺神经内分泌肿瘤均具有较高的淋巴管密度,对于前者可能意味着为淋巴结转移作准备。
Objective:To investigate the difference of the lymphatic vessel density(LVD) in pancreatic carcinoma(PC),neuroendocrine tumor of the pancreas(NETP),solid pseudopapillary tumor of the pancreas(SPTP) and cystadenoma of the pancreas(CP).Methods:Monoclonal antibody D2-40 was used immunohistochemically to detect the LVD in 33 PC,7 NETP,7 SPTP,3 CP.Results:The LVD of NETP was significantly higher than that of PC,SPTP,CP.The LVD of PC was significantly higher than that of SPTP and CP,but no difference between SPTP and CP.Conclusion:The LVD of NETP and PC are relatively higher than that of SPTP and CP,but it is of the preparation for lymph node metastasis only in PC.