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中文摘要：
为制备肿瘤增殖显像剂3′-脱氧-3′-氟胸腺嘧啶脱氧核苷（3′-deoxy-3′{luorothymidine，^18F-FLT），合成了标记前体3-N-t-叔丁氧羰基-1[5’0-（4，4′-二甲氧基三苯甲基）-2′-脱氧-3′-0-（4-硝基苯磺酰基-β-1）-苏戊呋喃糖]胸腺嘧啶脱氧核苷（N-BOC-FLT）并进行了标记。标记前体和各步合成中间体均经红外、核磁共振和质谱确证；于120℃进行亲核氟化反应，标记率为（35．2±5．8）％（经校正，n=2），用TLC和HPLC检测其放化纯度（RCP）大于95％，可满足临床研奔的要求。
英文摘要：
Synthesis and fluoro-radiolabeling of proliferation imaging agent 3′-deoxy-3′-1-18 F] fluorothymidine（18F-FLT）were reported. The chemical structure of the labeling precursor N- BOC-FLT and all its intermediates were verified by IR, MS and 1H NMR. Nucleophilic fluorination was proceeded at 120℃. Radiochemical yield is （35.2±5.8）% （n=2, decay corrected） and final radioehemical purity is above 95% determined by TLC and HPLC. Thereby it can be used preelinically.
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