中文摘要：

瞄准：检测杂合现象(LOH ) 和易碎的组氨酸三个一组(FHIT ) 的微卫星 instabi1ities (MSI ) 的损失在胃的癌并且到学习的基因他们有胃的癌的临床的病理学的特征的协会。方法：FHIT 基因的 LOH 和 MSI 与主要胃的癌症从 50 个病人在匹配的正常和癌的纸巾用 PCR 在四 microsaterllite 部位 D3Sl3H， D3S4l03， D3Sl48l 和 D3S1234 被检测。结果：LOH 的平均频率和在胃的癌症的 FHIT 基因的 MSI 分别地是 32.4% 和 26.4% 。在胃的癌症的 FHIT 基因的 LOH 和 MSI 没有协会与组织学， Borrmann，和 Lauren 的分类。在胃的癌症的 FHIT 基因的 LOH 与侵略深度有关。没有 serosa 穿入，在有 serosa 穿入的胃的癌症的 FHIT LOH 的频率在胃的癌症显然比那高(73.5% 对 37.5% ， P 【 0.05 ) 。在胃的癌症的 FHIT 基因的 MSI 与淋巴节点转移被联系。在没有淋巴节点转移的胃的癌症的 MSI 的频率在有淋巴节点转移的胃的癌症比那显著地高(66.7% 对 34.3% ， P 【 0.05 ) 。结论：FHIT 基因的 LOH 与胃的癌的侵略深度被相关。FHIT 基因的 MSI 与淋巴节点转移被相关。FHIT 基因的 LOH 和 MSI 在胃的癌症的致癌作用起一个重要作用。

英文摘要：

AIM： To detect the loss of heterozygosity （LOH） and microsatellite instabilities （MSI） of fragile histidine triad （FHIT） gene in gastric carcinoma and to study their association with the clinical pathological characteristics of gastric carcinoma. METHODS： LOH and MSI of FHIT gene were detected at four microsaterllite loci D3SI3H, D3S4103, D3SI481 and D3S1234 using PCR in matched normal and cancerous tissues from 50 patients with primary gastric cancer. RESULTS： The average frequency of LOH and MSI of FHIT gene in gastric cancer was 32.4% and 26.4% respectively. LOH and MSI of FHIT gene in gastric cancer had no association with histological, Borrmann, and Lauren＇s classification. LOH of FHIT gene in gastric cancer was related to invasive depth. The frequency of FHIT LOH in gastric cancer with serosa-penetration was obviously higher than that in gastric cancer without serosa-penetration （73.5% vs 37.5%, P 〈 0.05）. MSI of FHIT gene in gastric cancer was associated with the lymph node metastasis. The frequency of MSI in gastric cancer without lymph node metastasis was significantly higher than that in gastric cancer with lymph node metastasis （66.7% vs 34.3%, P 〈 0.05）. CONCLUSION： LOH of FHIT gene is correlated with invasive depth of gastric carcinoma. MSI of FHIT gene is correlated with lymph node metastases. LOH and MSI of FHIT gene play an important role in carcinogenesis of gastric cancer.