中文摘要：

文章介绍在放射治疗以后为侵略 aspergilloma 经历了部分肺切除术的一个 48 岁的白人的案例研究。CYP450 3A4 的 posaconazole 抑制引起了病人的提高的 topiramate 层次，这被假设。这也被报导以便证实相互作用并且阐明精确机制，在 posaconazole 和 topiramate 之间的相互作用的进一步的 pharmacokinetic 分析被保证。

英文摘要：

AIM： To analyze the differences and relevance of Yesassociated protein （YAP） and survivin, and to explore the correlation and significance of their expression in gastric carcinoma and precancerous lesions. METHODS： The PV9000 immunohistochemical method was used to detect the expression of YAP and survivin in 98 cases of normal gastric mucosa, 58 intestinal metaplasia （IM）, 32 dysplasia and 98 gastric carcinoma. RESULTS： The positive rates of YAP in dysplasia （37.5%） and gastric carcinoma （48.0%） were significantly higher than that in normal gastric mucosa （13.3%）, P 〈 0.01. The positive rates of survivin in IM （53.4%）, dysplasia （59.4%） and gastric carcinoma （65.3%） were significantly higher than in normal gastric mucosa （11.2%）, P 〈 0.01. Survivin expression gradually increased from 41.7% in well differentiated adenocarcinoma through 58.3% in moderately differentiated adenocarcinoma to 75.6% in poorly differentiated adenocarcinoma, with significant Rank correlation, rk = 0.279, P 〈 0.01. The positive rate of survivin in gastric carcinoma of diffused type （74.6%） was significantly higher than that in intestinal type （51.3%）, P 〈 0.05. In gastric carcinoma with lymph node metastasis （76.9%）, the positive rate of survivin was significantly higher than that in the group without lymph node metastasis （41.2%）, P 〈 0.01. In 98 cases of gastric carcinoma, the expression of YAP and of survivin were positively correlated, rk = 0.246, P 〈 0.01. CONCLUSION： YAP may play an important role as a carcinogenic factor and may induce survivin expression. Detecting both markers together may help in early diagnosis of gastric carcinoma.