中文摘要：

报道了新型空气动力辅助离子化（AFAI）装置与不同类型商业化质量分析器的快速接口技术.在前期研究基础上,进一步提高了AFAI系统的抽气流速,在更宽范围内考察了流速对质谱灵敏度的影响;对AFAI离子源进行模块化设计和制作,重点解决快速接口问题,通过更换接口板可实现其与不同厂家、不同类型质量分析器[飞行时间（TOF）、四级杆-离子阱（Q-TRAP）和四级杆-飞行时间（Q-TOF）]的兼容及联用,尤其可以与具有气帘接口的质量分析器联用.本离子源装置结合不同质量分析器可以进行全扫描、子离子扫描、母离子扫描、中性丢失扫描和高分辨等多种类型质谱分析,而且AFAI可在电喷雾（ESI）、解析电喷雾（DESI）和大气压化学电离（APCI）等多种离子化模式下工作,从而实现对不同性质化合物的快速检测.本研究结果进一步提高了AFAI离子化技术的功能,拓展了其应用范围.

英文摘要：

The growth of the field of ambient mass spectrometry（MS） is rapid because of its advantage on direct MS analysis with minimum or without sample pretreatment.Ion source is one of the key techniques for mass spectrometer.This paper described the advanced development of air flow assisted ionization ion source（AFAI） and its performance on various types of mass analyzer.The maximum extracting gas flow rate was improved up to 75 L/min,and the sensitivity of the AFAI was investigated with higher extracting gas flow rate.AFAI ion source was installed on various types of mass analyzer including time of flight（TOF）,Q-TRAP and Q-TOF via a corresponding modularized interface.Therefore,the full mass scan,product ion scan,precursor ion scan,neutral loss scan and accurate mass measurement would be carried out for ambient MS analysis with AFAI.The advanced development of the AFAI would promote its applications.