中文摘要：

氨甲蝶呤多聚谷氨酸（methotrexate polyglutamate,MTXPG）为氨甲蝶呤（methotrexate,MTX）在细胞内的代谢产物,其蓄积程度决定着MTX的细胞毒性和治疗效果。MTXPG的检测有利于监测其在细胞内的浓度,指导临床用药和预后判断。本文就MTXPG在细胞内的代谢过程、检测方法及其在临床疾病治疗中的应用价值做一综述。

英文摘要：

Methotrexate polyglutamate （MTXPG） is the intracellular metabolin of methotrexate, and the accumulation degree of MTXPG determines the intracellular toxicity and treatment effect of methotrexate. Detection of methotrexate polyglutamines is useful for monitoring its concentration in cells and for guiding clinical treatment and prognosis. This review is about the studies on intracellular metabolic process of methotrexate polyglutamates and the detection methods and treatment value of methotrexate polyglutamates in clinical diseases.