中文摘要：

以9-氨基-9-脱氧奎尼丁为催化剂,三氟乙酸为添加剂,乙腈为溶剂,吡唑啉-5-酮与1,5-二取代戊二烯-3-酮经不对称双Michael加成反应合成了一系列手性的螺[（吡唑啉-5-酮）-4,4＇-环己酮],收率42％～ 71％,72％ee ～ 97％ ee,其结构经1H NMR,13C NMR和HR-ESI-MS确证.

英文摘要：

A series of chiral spiro [（pyrazolin-5-one）-4,4＇-cyclohexanones] in yield of 42% ～ 71% with 72%ee～97%ee were synthesized by an asymmetric double Michael addition of pyrazolin-5-one with 1,5-disubstituted-pentylene-3-one using 9-amino-9-deoxyepiquinidine as the catalyst,trifluoroacetic acid as the additive and acetonitrile as the solvent.The structures were confirmed by 1H NMR,13C NMR and HR-ESI-MS.