以K2CO3为碱,β-酮酸酯与2-苯二甲酰亚氨基丙烯酸甲酯经共轭加成反应合成了一系列α-氨基酸衍生物,收率88%-99%,d/r值1.2:1~1.3:1,其结构经1HNMR,13CNMR和HR-MS(ESI—TOF)确证。
A serials of a-amino acid derivatives, in yields of 88% - 99% and d/r of 1.2 : 1 - 1.3 : 1, were synthesized by K2CO3-promoted conjugate addition of β-keto esters with methyl 2-phthalimidoacrylates. The structures were confirmed by 1H NMR, 13C NMR and HR-MS(ESI-TOF).