中文摘要：

利用NCBI数据库中小鼠Embryonic Stem Cells（ESC）与Neural Progenitor Cells（NPC）的基因芯片结果及NPC时期的RFX1ChIP—Seq数据，进行有关RFX1的分析，结果表明：RFXl结合位点富集在1，2，4，5，7，9，11染色体上，Y染色体上最少，其他染色体上比较均衡；在基因组中结合位点分布区域主要在基因的promoter区域，约有53．2％，其次是intergentic，占22．5％，body区域，占13．19／6，enhancer区域，占11．29／5．说明RFX1是以结合在基因的promoter区为主要形式对目的基因进行调控．同时在DAVID数据库中用生物信息学方法探索了RFX1靶基因的生物学功能分类．

英文摘要：

The datas of Neural Progenitor Cells chip and Embryonic Stem Cells ChlP-Seq from NCBI were analyzed to explore the function of RFX1. A comprehensive analysis showed that RFX1 binding sites spread across each chromosome. Most of them resided in chromosomes 1, 2, 4, 5, 7, 9 and 11, but the least in chromosome Y. And genome wide localization prediction showed that RFX1 binding sites ubiquitously and generally existed throughout the genome. 53.2% of these sequences were distributed in pro- moter, 22.5% in the intergentic, 13.1% in the body, and 11.2% in the enhancer in the mouse genome. In addition, the biological processes of RFX1 target genes were analyzed. The majority of the affected biological processes were mainly cellular and metabolic.