背景:在临床骨科研究方面,为了研究股骨头坏死的病因及发病机制,从根本上进行治疗,出现了各种各样的股骨头坏死的动物模型。 目的:对近几年来学者们建立的各种各样股骨头坏死的改良模型作一个综述,分析各种模型的优劣,用来指导临床对股骨头坏死发病机制进行研究或者评价一种新的治疗方法的临床价值。
BACKGROUND: In clinical orthopedic research, a variety of femoral head necrosis animal models have emerged in order to study the etiology and pathogenesis of femoral head necrosis and give a fundamental treatment. OBJECTIVE: To give a review to the variety of femoral head necrosis improved model established by scholars in recent years, and to analyze the pros and cons of various models, in order to help to study the osteonecrosis pathogenesis or evaluate the clinical value of a new treatment. METHODS: The CNKI database and PubMed database (2005 01/2011 12) were used to retrieve the articles on the establishment of femoral head necrosis animal models with the key words of "femoral head necrosis, animal model" in English and Chinese. A total of 136 articles were obtained and finally 16 articles were included to review according to the inclusion criteria. RESULTS AND CONCLUSION: The improved methods of steroid-induced are most used in modeling approach currently, but different modeling approach has its own advantages and disadvantages. Each method should be closely linked with its experimental purpose. And no matter for the study of the etiology and pathogenesis, or the evaluation of treatment, the methods to establish the animal model still needs further improvement.