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建立股骨头坏死动物模型的最新信息
  • ISSN号:2095-4344
  • 期刊名称:《中国组织工程研究》
  • 时间:0
  • 分类:R318[医药卫生—生物医学工程;医药卫生—基础医学]
  • 作者机构:[1]南京大学医学院临床学院(解放军南京军区南京总医院骨科),江苏省南京市210002
  • 相关基金:国家自然科学基金资助项目(81000792)~~
中文摘要:

背景:在临床骨科研究方面,为了研究股骨头坏死的病因及发病机制,从根本上进行治疗,出现了各种各样的股骨头坏死的动物模型。 目的:对近几年来学者们建立的各种各样股骨头坏死的改良模型作一个综述,分析各种模型的优劣,用来指导临床对股骨头坏死发病机制进行研究或者评价一种新的治疗方法的临床价值。

英文摘要:

BACKGROUND: In clinical orthopedic research, a variety of femoral head necrosis animal models have emerged in order to study the etiology and pathogenesis of femoral head necrosis and give a fundamental treatment. OBJECTIVE: To give a review to the variety of femoral head necrosis improved model established by scholars in recent years, and to analyze the pros and cons of various models, in order to help to study the osteonecrosis pathogenesis or evaluate the clinical value of a new treatment. METHODS: The CNKI database and PubMed database (2005 01/2011 12) were used to retrieve the articles on the establishment of femoral head necrosis animal models with the key words of "femoral head necrosis, animal model" in English and Chinese. A total of 136 articles were obtained and finally 16 articles were included to review according to the inclusion criteria. RESULTS AND CONCLUSION: The improved methods of steroid-induced are most used in modeling approach currently, but different modeling approach has its own advantages and disadvantages. Each method should be closely linked with its experimental purpose. And no matter for the study of the etiology and pathogenesis, or the evaluation of treatment, the methods to establish the animal model still needs further improvement.

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期刊信息
  • 《中国组织工程研究》
  • 北大核心期刊(2014版)
  • 主管单位:中华人民共和国卫生和计划生育委员会
  • 主办单位:中国康复医学会 《中国组织工程研究》杂志社
  • 主编:唐佩福
  • 地址:沈阳浑南新区10002邮政信箱
  • 邮编:110180
  • 邮箱:crter3377@163.com
  • 电话:024-31416864
  • 国际标准刊号:ISSN:2095-4344
  • 国内统一刊号:ISSN:21-1581/R
  • 邮发代号:8-584
  • 获奖情况:
  • 2001“百种中国杰出学术期刊,卫生部首届医药卫生优秀获奖期刊,北方优秀期刊,辽宁省一级期刊,第三、四届沈阳市优秀期刊一等奖
  • 国内外数据库收录:
  • 美国化学文摘(网络版),荷兰文摘与引文数据库,荷兰医学文摘,中国中国科技核心期刊,中国北大核心期刊(2008版),中国北大核心期刊(2014版)
  • 被引量:16688